FD ISO/TR 14735
Cosmetics - Analytical methods - Nitrosamines : technical guidance document for minimising and determining N-nitrosamines in cosmetics
ISO/TR 14735:2013 aims to contribute to providing general advice on strategies that can be adopted to minimize the likelihood of N-nitrosamine formation in cosmetic products and provide a description of the analytical methodologies available for the reliable determination of N-nitrosamines in cosmetic products. It also seeks to provide some insight into the relevance and limitations of each of the methods described and finally provide an analytical approach for the analysis of N-nitrosamines in cosmetic products and raw materials. ISO/TR 14735:2013 covers the reduction or elimination of adventitious nitrite sources, reduction or elimination of secondary amino sources, incorporation of inhibitors to N-nitrosamine formation and analytical methodologies for total N-nitroso compounds and specific methods for N-nitrosodiethanolamine (NDELA).
ISO/TR 14735:2013 aims to contribute to providing general advice on strategies that can be adopted to minimize the likelihood of N-nitrosamine formation in cosmetic products and provide a description of the analytical methodologies available for the reliable determination of N-nitrosamines in cosmetic products. It also seeks to provide some insight into the relevance and limitations of each of the methods described and finally provide an analytical approach for the analysis of N-nitrosamines in cosmetic products and raw materials.
ISO/TR 14735:2013 covers the reduction or elimination of adventitious nitrite sources, reduction or elimination of secondary amino sources, incorporation of inhibitors to N-nitrosamine formation and analytical methodologies for total N-nitroso compounds and specific methods for N-nitrosodiethanolamine (NDELA).
- Avant-proposiv
- Introductionv
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1 Domaine d'application1
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2 Composition chimique des N-nitrosamines1
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3 Stratégies de limitation1
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3.1 Réduction ou élimination des sources accidentelles de nitrite1
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3.2 Réduction ou élimination des sources de composés amines secondaires2
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3.3 Incorporation d'inhibiteurs de la formation de nitrosamines2
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3.4 Traitement potentiel des matières premières cosmétiques pour la décomposition des N-nitrosamines3
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4 Méthodes analytiques3
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4.1 Recherche des composés N-nitrosés dans les produits cosmétiques par détection chimiluminescente de l'oxyde nitrique3
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4.2 Teneur apparente en nitrosamines totales (TANT)3
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4.3 Méthodes relatives à la NDELA4
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4.4 Détermination d'autres N-nitrosamines spécifiques5
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5 Approche analytique5
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5.1 Généralités5
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5.2 Screening5
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5.3 Mesurage de N-nitrosamines spécifiques6
- Annexe A (informative) Composés référencés comme inhibiteurs8
- Bibliographie9
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