NF ISO 19238

December 2005

Standard Cancelled

Radiation protection - Performance criteria for service laboratories performing biological dosimetry by cytogenetics

ISO 19238:2004 provides criteria for quality assurance and quality control, evaluation of the performance and the accreditation of biological dosimetry by cytogenetic service laboratories.

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Main informations

Collections

National standards and national normative documents

Thematics

Sécurité, Gestion des risques et SST, QSE

Publication date

December 2005

Number of pages

28 p.

Reference

NF ISO 19238

ICS Codes

13.280 Radiation protection

17.240 Radiation measurements

Classification index

M60-220

Print number

1 - 14/11/2005

International kinship

ISO 19238:2004

Sumary

Radiation protection - Performance criteria for service laboratories performing biological dosimetry by cytogenetics

ISO 19238:2004 provides criteria for quality assurance and quality control, evaluation of the performance and the accreditation of biological dosimetry by cytogenetic service laboratories.

Standard replaced by (1)

NF ISO 19238

April 2014

Standard Cancelled

Radiation protection - Performance criteria for service laboratories performing biological dosimetry by cytogenetics

ISO 19238:2014 provides criteria for quality assurance and quality control, evaluation of the performance, and the accreditation of biological dosimetry by cytogenetic service laboratories. ISO 19238:2014 addresses a) the confidentiality of personal information, for the customer and the service laboratory, b) the laboratory safety requirements, c) the calibration sources and calibration dose ranges useful for establishing the reference dose-effect curves that contribute to the dose estimation from chromosome aberration frequency and the minimum resolvable doses, d) the scoring procedure for unstable chromosome aberrations used for biological dosimetry, e) the criteria for converting a measured aberration frequency into an estimate of absorbed dose, f) the reporting of results, g) the quality assurance and quality control, h) informative annexes containing sample instructions for customer, sample questionnaire, sample of report, fitting of the low dose-response curve by the method of maximum likelihood and calculating the error of dose estimate, odds ratio method for cases of suspected exposure to a low dose, and sample data sheet for recording aberrations.

Table of contents

Avant-propos
v
Introduction
vi
1 Domaine d'application
1
2 Termes et définitions
1
3 Dénombrement des dicentriques
3
4 Confidentialité des informations personnelles
4
4.1 Généralités
4
4.2 Applications du principe de confidentialité
4
5 Exigences de sécurité du laboratoire
5
5.1 Généralités
5
5.2 Exigences de sécurité microbiologique
5
5.3 Exigences de sécurité chimique
5
5.4 Exigences de sécurité optique
7
5.5 Procédures de sécurité
7
6 Source(s) d'étalonnage, courbes(s) d'étalonnage et seuils de détection
7
6.1 Source(s) d'étalonnage
7
6.2 Courbe(s) d'étalonnage
7
6.3 Seuils limite de détection
7
7 Responsabilité du demandeur
8
8 Responsabilité du laboratoire de service
8
9 Dénombrement des aberrations chromosomiques instables
9
9.1 Procédure pour l'analyse des métaphases en première division
9
9.2 Critères pour le dénombrement
9
10 Critères pour convertir une fréquence d'aberration mesurée en une estimation de dose absorbée
10
10.1 Généralités
10
10.2 Comparaison avec les valeurs témoins
10
10.3 Détermination de l'estimation de dose et des limites de l'intervalle de confiance
10
10.4 Cas d'exposition aiguë et non aiguë
11
10.5 Cas d'exposition hétérogène ou ancienne
11
11 Compte rendu des résultats
11
11.1 Identification du sujet exposé
11
11.2 Description du cas
12
11.3 Obligations du laboratoire de service
12
11.4 Résultats du laboratoire de service
12
11.5 Interprétation des résultats
12
11.6 Responsable du rapport
12
11.7 Résumé
12
12 Assurance de la qualité et contrôle de la qualité
13
12.1 Généralités
13
12.2 Assurance de la qualité
13
12.3 Contrôle de la qualité
15
Annexe A (informative) Instructions pour le demandeur (exemple)
17
Annexe B (informative) Exemple de questionnaire
18
Annexe C (informative) Tableau type pour le dénombrement des aberrations chromosomiques
20
Annexe D (informative) Exemple de rapport
21
Bibliographie
22

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