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National standards and national normative documents

Publication date

May 2024

Number of pages

26 p.

Reference

NF ISO 21766

ICS Codes

65.160 Tobacco, tobacco products and related equipment

Classification index

V37-206

Print number

1

International kinship

ISO 21766:2021

Sumary

Tobacco and tobacco products - Determination of tobacco-specific nitrosamines in tobacco products - Method using LC-MS/MS

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in tobacco and the following tobacco products: cigarettes, cigars and smokeless tobacco products using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The TSNAs determined with this method are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Replaced standards (1)

NF ISO 21766

February 2019

Standard Cancelled

Tobacco and tobacco products - Determination of tobacco-specific nitrosamines in tobacco products - Method using LC-MS/MS

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in tobacco and the following tobacco products: cigarettes, cigars and smokeless tobacco products using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The TSNAs determined with this method are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Standard replaced by (1)

NF ISO 21766

February 2019

Standard Cancelled

Tobacco and tobacco products - Determination of tobacco-specific nitrosamines in tobacco products - Method using LC-MS/MS

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in tobacco and the following tobacco products: cigarettes, cigars and smokeless tobacco products using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The TSNAs determined with this method are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Table of contents

1 Domaine d'application
2 Références normatives
3 Termes et définitions
4 Principe
5 Réactifs
6 Appareillage
7 Préparation
8 Échantillonnage
9 Analyse des échantillons
10 Répétabilité et reproductibilité
11 Rapport d'essai
Annexe A Nettoyage de l'échantillon par extraction en phase solide (SPE)
Annexe B Exemples de chromatogrammes types
Bibliographie

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