NF ISO 19290

NF ISO 19290

October 2021
Standard Current

Cigarettes - Determination of tobacco specific nitrosamines in mainstream cigarette smoke - Method using LC-MS/MS

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of mainstream cigarette smoke by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

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Main informations

Collections

National standards and national normative documents

Publication date

October 2021

Number of pages

20 p.

Reference

NF ISO 19290

ICS Codes

65.160   Tobacco, tobacco products and related equipment

Classification index

V37-199

Print number

1

International kinship

ISO 19290:2021
Sumary
Cigarettes - Determination of tobacco specific nitrosamines in mainstream cigarette smoke - Method using LC-MS/MS

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of mainstream cigarette smoke by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Replaced standards (1)
NF ISO 19290
January 2017
Standard Cancelled
Cigarettes - Determination of tobacco specific nitrosamines in mainstream cigarette smoke - Method using LC-MS/MS

Le présent document spécifie une méthode de quantification de quatre nitrosamines spécifiques du tabac (TSNAs) dans la matière particulaire totale du courant principal de la fumée de cigarette par chromatographie liquide haute performance en phase inverse avec détection par spectrométrie de masse en tandem (CL-SM/SM) . Les TSNAs quantifiées sont les suivantes : N-nitrosonornicotine (NNN) , N-nitrosoanatabine (NAT) , N?nitrosoanabasine (NAB) et 4- (méthylnitrosamino) -1- (3-pyridyl) -1-butanone (NNK) .

Table of contents
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  • Avant-propos
  • 1 Domaine d'application
  • 2 Références normatives
  • 3 Termes et définitions
  • 4 Principe
  • 5 Appareillage
  • 6 Réactifs
  • 7 Préparation
  • 8 Échantillonnage
  • 9 Préparation du produit du tabac
  • 10 Production de l'échantillon - Fumage de cigarettes
  • 11 Analyse de l'échantillon
  • 12 Répétabilité et reproductibilité
  • 13 Rapport d'essai
  • Annexe A (informative) Exemples de chromatogrammes types
  • Bibliographie
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