NF ISO 21243

September 2009

Standard Cancelled

Radiation protection - Performance criteria for laboratories performing cytogenetic triage for assessment of mass casualties in radiological or nuclear emergencies - General principles and application to dicentric assay

ISO 21243:2008 is to give an overview of the minimum requirements of process and quality-control components of the cytogenetic response for triage of mass casualties. Cytogenetic triage is the use of chromosome damage to evaluate approximately and rapidly radiation doses received by individuals in order to supplement the early clinical categorization of casualties. ISO 21243:2008 concentrates on organizational aspects of applying the dicentric assay for operation in a triage mode. The technical aspects of the dicentric assay can be found in the ISO 19238, ISO 21243:2008 is applicable either to an experienced biological dosimetry laboratory working alone or to a network of collaborating laboratories.

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Main informations

Collections

National standards and national normative documents

Thematics

Sécurité, Gestion des risques et SST, QSE

Publication date

September 2009

Number of pages

30 p.

Reference

NF ISO 21243

ICS Codes

13.280 Radiation protection

27.120.20 Nuclear power plants. Safety

Classification index

M60-525

Print number

1 - 15/09/2009

International kinship

ISO 21243:2008

Sumary

Radiation protection - Performance criteria for laboratories performing cytogenetic triage for assessment of mass casualties in radiological or nuclear emergencies - General principles and application to dicentric assay

Standard replaced by (1)

NF ISO 21243

January 2023

Standard Current

Radiation protection - Performance criteria for laboratories performing initial cytogenetic dose assessment of mass casualties in radiological or nuclear emergencies - General principles and application to dicentric assay

The purpose of this document is to give an overview of the minimum requirements for performing the dicentric assay with quality control measures using mitogen stimulated peripheral blood lymphocytes for initial assessment of individuals involved in a mass casualty scenario. The dicentric assay is the use of chromosome damage to quickly estimate approximate radiation doses received by individuals in order to supplement the early clinical categorization of casualties. This document focuses on the organizational and operational aspects of applying the dicentric assay in an initial assessment mode. The technical aspects of the dicentric assay can be found in ISO 19238. This document is applicable either to an experienced biological dosimetry laboratory working alone or to a network of collaborating laboratories (as defined in Clause 7).

Table of contents

Avant-propos
iv
Introduction
v
1 Domaine d'application
1
2 Références normatives
1
3 Termes et définitions
1
4 Abréviations
4
5 Planification préalable
4
5.1 Sensibilisation à la norme
4
5.2 Rôles et responsabilités des structures de soins
4
5.3 Rôles et responsabilités des laboratoires pratiquant la dosimétrie biologique
5
6 Communication et information
6
6.1 Demande de dosimétrie biologique et confidentialité
6
6.2 Programme d'enseignement - Mise à niveau, formation et exercices pratiques
6
7 Procédure de dosimétrie biologique en cas d'incident radiologique ou nucléaire impliquant un très grand nombre de victimes
7
8 Intervention d'urgence du laboratoire de référence
7
9 Constitution du réseau de laboratoires
7
9.1 Généralités
7
9.2 Préparation du réseau de laboratoires
8
9.3 Fonctionnement du réseau de laboratoires
9
10 Résultats attendus
9
10.1 Généralités
9
10.2 Exposition du corps entier
10
10.3 Exposition non homogène
11
11 Assurance de la qualité et contrôle de la qualité
11
11.1 Généralités
11
11.2 Contrôle de la qualité
11
Annexe A (normative) Interactions entre médecins et laboratoires de dosimétrie biologique
14
Annexe B (informative) Formulaire de prise de contact initiale
15
Annexe C (informative) Guide relatif au seuil de détection
16
Annexe D (informative) Estimations de doses et limites de l'intervalle de confiance à 95 % pour certaines fréquences observées de dicentriques et de cellules
17
Annexe E (informative) Instructions pour le demandeur
18
Annexe F (informative) Exemple de rapport de tri
19
Bibliographie
21

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