NF ISO 21243

NF ISO 21243

January 2023
Standard Current

Radiation protection - Performance criteria for laboratories performing initial cytogenetic dose assessment of mass casualties in radiological or nuclear emergencies - General principles and application to dicentric assay

The purpose of this document is to give an overview of the minimum requirements for performing the dicentric assay with quality control measures using mitogen stimulated peripheral blood lymphocytes for initial assessment of individuals involved in a mass casualty scenario. The dicentric assay is the use of chromosome damage to quickly estimate approximate radiation doses received by individuals in order to supplement the early clinical categorization of casualties.This document focuses on the organizational and operational aspects of applying the dicentric assay in an initial assessment mode. The technical aspects of the dicentric assay can be found in ISO 19238.This document is applicable either to an experienced biological dosimetry laboratory working alone or to a network of collaborating laboratories (as defined in Clause 7).

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Main informations

Collections

National standards and national normative documents

Thematics

QSE, Gestion des risques et SST, Sécurité

Publication date

January 2023

Number of pages

30 p.

Reference

NF ISO 21243

ICS Codes

13.280   Radiation protection
27.120.20   Nuclear power plants. Safety

Classification index

M60-525

Print number

1

International kinship

ISO 21243:2022
Sumary
Radiation protection - Performance criteria for laboratories performing initial cytogenetic dose assessment of mass casualties in radiological or nuclear emergencies - General principles and application to dicentric assay

The purpose of this document is to give an overview of the minimum requirements for performing the dicentric assay with quality control measures using mitogen stimulated peripheral blood lymphocytes for initial assessment of individuals involved in a mass casualty scenario. The dicentric assay is the use of chromosome damage to quickly estimate approximate radiation doses received by individuals in order to supplement the early clinical categorization of casualties.

This document focuses on the organizational and operational aspects of applying the dicentric assay in an initial assessment mode. The technical aspects of the dicentric assay can be found in ISO 19238.

This document is applicable either to an experienced biological dosimetry laboratory working alone or to a network of collaborating laboratories (as defined in Clause 7).

Replaced standards (1)
NF ISO 21243
September 2009
Standard Cancelled
Radiation protection - Performance criteria for laboratories performing cytogenetic triage for assessment of mass casualties in radiological or nuclear emergencies - General principles and application to dicentric assay

ISO 21243:2008 is to give an overview of the minimum requirements of process and quality-control components of the cytogenetic response for triage of mass casualties. Cytogenetic triage is the use of chromosome damage to evaluate approximately and rapidly radiation doses received by individuals in order to supplement the early clinical categorization of casualties. ISO 21243:2008 concentrates on organizational aspects of applying the dicentric assay for operation in a triage mode. The technical aspects of the dicentric assay can be found in the ISO 19238, ISO 21243:2008 is applicable either to an experienced biological dosimetry laboratory working alone or to a network of collaborating laboratories.

Table of contents
  • 1 Domaine d'application
  • 2 Références normatives
  • 3 Termes et définitions
  • 4 Responsabilité du laboratoire
  • 5 Procédure de dosimétrie biologique en cas d'incident radiologique ou nucléaire impliquant un très grand nombre de victimes
  • 6 Intervention d'urgence du laboratoire de référence
  • 7 Constitution d'un réseau de laboratoires
  • 8 Résultats attendus
  • 9 Assurance qualité et contrôle qualité
  • Annexe A (informative) Interactions entre demandeurs et laboratoires de dosimétrie biologique
  • Annexe B (informative) Recommandations relatives au seuil de détection lorsque le test dicentrique est réalisé en comptage
  • Annexe C (informative) Exemple de rapport d'estimation de dose pour plusieurs échantillons
  • Bibliographie
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